PROGRAM | Hcy2021

PROGRAM

The organizer reserves the right to make changes to the conference program.

September 12, 2021 - SUNDAY

14:00 - 19:50 | SESSION 1
Genetics and Epigenetics of Hyperhomocysteinemia
Chair: Viktor Kožich, Warren Kruger, Hieronim Jakubowski

14:00 - 14:30

Cystathionine beta-synthase deficiency: six decades of research and recent contribution of the E-HOD consortium
Viktor Kožich

14:30 - 15:00

Molecular Bases of Cystathionine β-synthase Deficiency
Hieronim Jakubowski

15:00 - 15:30

Long-term functional correction of cystathionine β-synthase deficiency in mice by adeno-associated viral gene therapy
Warren D. Kruger

15:30 - 15:45

Dysregulation of sulfur metabolome in murine homocystinuria
Tomas Majtan

15:45 - 16:00

Structural insight into the unique conformation of Cystathionine β-synthase from Toxoplasma gondii
Luis Alfonso Martinez-Cruz

16:00 - 16:15

COVID-19 pandemic impact in a sample of 34 Brazilian patients with classic homocystinuria and methylmalonic acidemia type cblC
Ida Vanessa Doederlein Schwartz

16:15 - 16:35

Discussion

16:35 - 17:25

Lunch

17:25 - 17:55

MTHFR deficiency in mice, due to genetic mutation or high folate diet, leads to hyperhomocysteinemia, altered choline/methyl metabolism and disturbances in liver and brain function
Rima Rozen

17:55 - 18:20

MTHFR and risk of stroke, ischemic heart disease and other non-vascular diseases: a Mendelian randomization study of >150,000 Chinese adults
Robert Clarke

18:20 - 18:35

Biochemical Studies in Patients with Mutations in the MTHFD1 gene encoding Methylenetetrahydrofolate Dehydrogenase 1
David Watkins

18:35 - 18:50

Probing the functional consequence and clinical relevance of CD320 p.E88del, a variant in the transcobalamin receptor gene
Faith Pangilinan

18:50 - 19:05

The endogenous human Dihydrofolate reductase 2 gene is not translated into a mitochondrial reductase enzyme
Niamh Bookey

19:05 - 19:20

The BHMT-betaine pathway epigenetically influences oligodendrocytes
Sarah Sternbach

19:20 - 19:50

Discussion

19:50 - 21:10

Welcome reception

September 13, 2021 - MONDAY

14:00 - 22:15 | SESSION 2
Homocysteine and CVD and Nervous System
Chair: Helga Refsum, Amany Elshorbagy, Hong Wang

13:15 - 14:00

Lunch

14:00 - 14:30

Cardiovascular Manifestations of Intermediate and Major Hyperhomocysteinemia Due to Vitamin B12 and Folate deficiency and/or Inherited Disorders of One-Carbon Metabolism: A 3.5-years Retrospective Cross-sectional Study of Consecutive Patients
Jean-Louis Guéant

14:30 - 15:00

Nuclear One-Carbon Metabolism and Folate-Associated Pathologies
Patrick Stover

15:00 - 15:30

The link between one-carbon metabolism and lipid metabolism
Agata Chmurzyńska

15:30 - 15:45

Associations of homocysteine-thiolactone, cysteinyl-glycine, and cysteine with stroke
Ewa Bretes

15:45 - 16:00

Evaluation of pathologies associated with hyperhomocysteinemia in human autopsy brain tissue
Erica Weekman

16:00 - 16:15

A Healthy Nordic Diet and its associations with plasma levels of metabolites of the choline oxidation pathway: A cross-sectional study based on data from Northern Sweden
André Heselink

16:15 - 16:45

Discussion

16:45 - 17:00

Break

17:00 - 17:30

The High Folate/Low B12 Interaction is a Novel Cause of Vitamin B12 Depletion with a Specific Etiology: A Hypothesis
Joshua Miller

17:30 - 18:00

Homocysteine-methionine cycle as a metabolic sensor system for methylation-regulated pathological signaling
Hong Wang

18:00 - 18:30

The plasma sulfur amino acid profile – possible determinants and associations with health outcomes
Amany Elshorbagy

18:30- 18:45

Subclinical inflammation, telomere shortening, homocysteine, B vitamins, and mortality: the LURIC study
Wolfgang Herrmann

18:45 - 19:00

Serum folate forms in fasting US adults by folic acid intake sources, NHANES 2011-2018
Christine Pfeiffer

19:00 - 19:15

Discussion
Break

19:15 - 19:30

One-carbon metabolism and L-Arginine pathway interaction is associated with increased risk of hypertension
Carla Ramos-Rodriguez

19:30 - 19:45

Age - and ethnicity-related references intervals for serum vitamin B12
Agata Sobczyńska-Malefora

19:45 - 20:00

A dietary vitamin B12 deficiency impairs motor function, neuronal survival, and choline metabolism after ischemic stroke to the sensorimotor cortex in adult male and female mice
Nafisa Jadavji

20:00 - 20:15

Involvement of homocysteine in atherosclerosis-related changes in the aortic rabbit wall in the absence and presence of hypercholesterolemia
Oksana Tehlivets

20:15 - 20:30

Discussion

20:30 - 20:45

Break

20:45 - 22:15 | SESSION 3
Microbiome and One-carbon Metabolism in Health and Disease
Chair: Agata Chmurzyńska, Suresh Tyagi

20:45 - 21:15

Dysbiotic 1-Carbon Metabolism in Growth Retardation
Suresh Tyagi

21:15 - 21:30

The impact of folate biosynthesis by Lactobacillus plantarum on colonic health in mice
Dieuwertje Kok

21:30 - 21:45

Classical homocystinuria: the relationship between the gut microbiota and short-chain fatty acids
Ida Vanessa Doederlein Schwartz

21:45 - 22:00

Associations of atrophic gastritis with vitamin B12 status and bone mineral density in older adults from the TUDA study
Michelle Clements

22:00 - 22:15

Discussion

September 14, 2021 - TUESDAY

14:00 - 19:10 | SESSION 4
Homocysteine and Neurodegeneration
Chair: A. David Smith, Domenico Praticò, Richard E. Frye

14:00 - 14:30

GlyNAC supplementation improves mitochondrial dysfunction, oxidative stress, inflammation, metabolic defects and aging hallmarks to improve muscle strength and reverse cognitive decline in aging
Rajagopal V. Sekhar

14:30 - 15:00

One-Carbon Metabolism Abnormalities in Autism Spectrum Disorder
Richard E. Frye

15:00 - 15:30

Methylation status and sulfur amino-acids as risk factors for cognitive decline over 15 years: A longitudinal population based study
Babak Hooshmand

15:30 - 16:00

It is well past time to apply our understanding of homocysteine metabolism to the treatment and prevention of age related Vascular Dementia
Irwin Rosenberg

16:00 - 16:20

Discussion

16:20 - 17:05

Lunch

17:05 - 17:35

Homocysteine and the pathophysiology of Alzheimer’s disease
Domenico Praticò

17:35 - 17:50

One-Carbon Metabolism in Brain Cortex in Alzheimer's and Parkinson's Disease in Relation to Cognitive Impairment
Karel Kalecký

17:50 - 18:05

Phf8-mediated epigenetic dysregulation of mTOR/autophagy increases amyloid beta accumulation and cognitive deficits in hyperhomocysteinemic and bleomycin hydrolase-deficient mice
Łukasz Witucki

18:05 - 18:20

Prenatal hyperhomocysteinemia upregulates mTOR signaling, downregulates autophagy, and increases accumulation of amyloid beta and tau in adult 3xTG-AD mice
Joanna Suszyńska-Zajczyk

18:20 - 18:35

Prenatal administration of SRT2104, a SIRT1 activating compound, reduces the cognitive defects associated with methionine synthase deficiency in mice
Manon Jeandel

18:35 - 18:50

Disruption of the one carbon metabolism could be a risk factor in Huntington’s disease
Carine Bossenmeyer-Pourié

18:50 - 19:10

Discussion

19:10 - 19:25

Break

19:25 - 21:00 | SESSION 5
Protein Modification by Homocysteine in Health and Disease
Chair: Hieronim Jakubowski, Jean-Louis Guéant

19:25 - 19:55

N-Homocysteinylation: Identification, pathological mechanisms, genetic factors, treating strategies and demodification
Xinyu Mei

19:55 - 20:10

B vitamins prevent negative effects of anti-N-Hcy-protein autoantibodies on cognition in mild cognitive impairment
Olga Włoczkowska

20:10 - 20:25

Leptin receptor antagonists reduces fibrinogen hyper-N-homocysteinylation in diet-induced obesity
Jerzy Bełtowski

20:25 - 20:40

The yeast map of protein lysine N-homocysteinylation
Joanna Perła-Kaján

20:40 - 21:00

Discussion

21:00 - 22:00 | VIRTUAL POSTER SESSION
Posters are listed in the PDF download file

September 15, 2021 - WEDNESDAY

13:15 - 14:00

Lunch

14:00 - 15:30 | SESSION 6
Methionine, One-carbon Metabolism, and Life Span
Chair: Rima Rozen, Joshua Miller, Babak Hooshmand

14:00 - 14:15

Mitochondrial dysfunction associated with cblC and cblG inherited defects of cobalamin metabolism fibroblasts can be corrected by the SIRT1 activating compound SRT2104
Ziad Hassan

14:15 - 14:30

Influence of methionine synthase on proliferation and differentiation of neural stem cells and postnatal neurogenesis. Study in the Mtr-KOc mouse model
Karim Matmat

14:30 - 14:45

Efficacy and pharmacokinetics of betaine in CBS and cblC deficiency: a cross over randomized controlled trial
Apolline Imbard

14:45 - 15:00

Maternal choline, folate and lutein intakes during pregnancy were positively associated with developmental outcomes in children at 2 years of age
Xinyin Jiang

15:00 - 15:15

Tracing Metabolic Fate of Mitochondrial Glycine Cleavage System Derived Formate In Vitro and In Vivo
En-Pei Isabel Chiang

15:15 - 15:30

Discussion

15:30 - 15:45

Break

15:45 - 18:30 | SESSION 7
B-vitamins, Homocysteine, Early Development and Pregnancy Outcomes
Chair: Michelle M. Murphy, David S. Rosenblatt

15:45 - 16:15

The U-shaped curve of folic acid and birth defect prevention: Can there be too much of a good thing?
John Steele for Richard H. Finnell

16:15 - 16:45

Maternal and paternal folate and cobalamin status, pregnancy outcome and early development. The Reus-Tarragona Birth Cohort Study
Michelle M. Murphy

16:45 - 17:00

Investigating interactions between mitochondrial one-carbon metabolism and the canonical Wnt co-receptor, LRP6, in neural tube defect models
John Steele

17:00 - 17:15

Interactions between mild choline deficiency and MTHFD1-synthetase deficiency increase incidence of embryonic defects in mice
Karen E. Christensen

17:15 - 17:30

Associations between pregnancy homocysteine and cobalamin status and metabolic score in the offspring
Alejandra Rojas-Gómez

17:30 - 17:45

Mutations in Hcfc1 and Ronin (Thap11) result in both an inborn error of cobalamin metabolism and a ribosomopathy impacting embryonic development
Ross Poche

14:45- 18:00

Cobalamin, MMACHC and the methionine dependence of cancer cells
Mark Sorin

18:00 - 18:30

Discussion

19:30

Gala Dinner

September 16, 2021 - THURSDAY

13:15 - 14:00

Lunch

14:00 - 17:15 | SESSION 8
Homocysteine, One-carbon Metabolism, and Cancer
Chair: Amanda J. MacFarlane, Joel Mason, Ruma Banerjee

14:00 - 14:30

H2S targets mitochondrial bioenergetics and induces metabolic remodeling
Ruma Banerjee

14:30 - 15:00

Folate intake and genome stability – a complex relationship
Amanda J. MacFarlane

15:00 - 15:15

Assessment of B12 vitamin status in patients with Gaucher disease type I.
Ida Vanessa Doederlein Schwartz

15:15 - 15:30

Insights into genetic and nutritional determinants of uracil accumulation in mitochondrial DNA
Martha Field

15:30 - 15:45

Loss of SHMT2 and folate deficiency impair energy metabolism in mouse embryonic fibroblasts cells
Joanna Fiddler

15:45 - 16:00

Dimer-dimer interface interactions involving R85 and T63 are key for methionine adenosyltransferase MATα1 tetramerization and kinetics
María Ángeles Pajares

16:00 - 16:15

Modulation of L-cysteine metabolism in human brain cancer 1321N1 and T98 cells differing in the degree of malignancy
Halina Jurkowska

16:15 - 16:45

Discussion

16:45 - 16:55 | Closing remarks

16:55 - 17:15 | Business meeting

Posters are listed in the pdf download file.